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Leptin's Immune Action: A Review Beyond Satiety
Alice Abend Bardagi1, Clarissa Dos Santos Paschoal1, Giovanna Ganem Favero1
1Center for Health Sciences, School of Medical Sciences, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, Brazil.
Immunological Investigations
|October 24, 2022
Summary
Leptin, a hormone from adipose tissue, regulates satiety, metabolism, and immune responses. This review explores leptin
Area of Science:
- Endocrinology and Immunology
- Adipokine signaling and immune cell regulation
- Hematopoiesis and metabolic homeostasis
Background:
- Adipose tissue functions as an endocrine organ, secreting key adipokines like leptin.
- Leptin is vital for regulating satiety, metabolism, and energy balance.
- Immune cells express leptin receptors, mediating leptin's influence on innate and adaptive immunity.
Approach:
- Review of existing literature on leptin's roles within and beyond the bone marrow.
- Examination of leptin receptor expression in hematopoietic stem cells and mature immune cells.
- Analysis of leptin-mediated signaling pathways, including JAK/STAT, PI3K, and ERK 1/2.
Key Points:
- Leptin receptors are present on hematopoietic stem cells and mature immune cells.
- Leptin signaling influences immune responses and hematopoiesis.
- Leptin-producing adipocytes in bone marrow play a role in hematopoiesis via poorly understood mechanisms.
Conclusions:
- Leptin's functions extend beyond satiety control, impacting immune regulation and hematopoiesis.
- Further research is needed to elucidate the precise mechanisms of leptin in bone marrow and immune function.
- Understanding leptin's multifaceted roles is crucial for metabolic and immune health.
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