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Updated: Aug 24, 2025

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The PharmNet Harm Reduction Intervention for Community Pharmacies: Protocol for a Pilot Randomized Controlled Trial.

Lori Ann Eldridge1, Jon Agley2, Beth E Meyerson3,4

  • 1East Carolina University, Greenville, NC, United States.

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|October 24, 2022
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Summary

This pilot study tested the PharmNet intervention to increase naloxone dispensing in rural pharmacies. PharmNet showed promise for boosting naloxone access, warranting further large-scale trials to combat the overdose epidemic.

Keywords:
PharmNetRCTcommunity healthdigital health interventiondrug usehealth outcomehealth resourcesnaloxoneopioidopioid useoverdosepharmacypreventionrandomized controlled trial

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Area of Science:

  • Public Health
  • Pharmacy Practice
  • Opioid Overdose Prevention

Background:

  • The US overdose epidemic persists despite harm reduction efforts.
  • Naloxone (an opioid antagonist) is crucial for reducing fatal overdoses.
  • Community pharmacies are ideal for naloxone dispensing, but current rates are low.

Purpose of the Study:

  • To evaluate if the PharmNet intervention increases naloxone dispensing compared to a control group.
  • To determine the feasibility of a large-scale randomized controlled trial of PharmNet.

Main Methods:

  • A 3-month randomized controlled pilot trial with 7 rural Indiana pharmacies (4 intervention, 3 control).
  • Primary outcome: overall naloxone dispensing (at cost and free).
  • Data collected pre- and post-intervention; analyzed using a generalized linear mixed model.

Main Results:

  • Study approved by Indiana University IRB; funded by IU Grand Challenge.
  • This section is not detailed in the provided abstract, but the study design is outlined.

Conclusions:

  • If PharmNet increases naloxone dispensing, a large-scale trial is warranted.
  • This research aims to improve community pharmacy engagement in naloxone distribution.