PRKCD as a potential therapeutic target for chronic obstructive pulmonary disease

Area of Science:

• Respiratory Medicine
• Molecular Biology
• Pharmacology

Background:

• Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease causing significant global morbidity and mortality.
• Despite available treatments, novel therapeutic targets for COPD are urgently needed.
• Protein kinase C delta (PRKCD) has emerged as a key player in COPD pathogenesis, though its precise mechanisms remain unclear.

Purpose of the Study:

• To review the roles and elucidate the mechanisms of PRKCD in the development of COPD.
• To consolidate current research on PRKCD's involvement in COPD pathogenesis.
• To identify PRKCD as a potential therapeutic target for COPD.

Main Methods:

• Systematic literature review of studies on PRKCD in COPD.
• Searches conducted on MEDLINE/PubMed databases.
• Synthesis of research progress on PRKCD and COPD.

Main Results:

• PRKCD promotes inflammatory responses in COPD.
• PRKCD contributes to apoptosis in the context of COPD.
• PRKCD is implicated in mitochondrial dysfunction and MUC5AC hypersecretion in COPD development.

Conclusions:

• PRKCD plays a significant role in the pathogenesis of COPD.
• PRKCD's mechanisms involve promoting inflammation, apoptosis, mitochondrial dysfunction, and MUC5AC hypersecretion.
• PRKCD represents a promising therapeutic target for managing COPD.