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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Toxicological and Exposure Database Inventory: A review.

Pascal Petit1

  • 1Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, CHU Grenoble Alpes, TIMC, 38000, Grenoble, France; CHU Grenoble Alpes, Centre Régional de Pathologies Professionnelles et Environnementales, Grenoble, France; Univ. Grenoble Alpes, AGEIS, 38000, Grenoble, France.

International Journal of Hygiene and Environmental Health
|October 24, 2022
PubMed
Summary

A new online inventory, the Toxicological and Exposure Database Inventory (TEDI), was created to help researchers find crucial data on chemical hazards and human exposure. This resource aims to improve health risk assessments by organizing vital toxicological and exposure information.

Keywords:
Chemical exposomeExposure databaseHealth risk assessmentInventoryToxicological database

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Public Health

Background:

  • Knowledge of chemical hazards and exposure data is essential for epidemiological studies and disease prevention.
  • Existing databases (DBs) for this information are often difficult to locate and navigate.
  • The chemical exposome presents a complex challenge for human health risk assessment.

Purpose of the Study:

  • To create a centralized, searchable online inventory of toxicological and exposure databases.
  • To support human health risk assessment by consolidating access to chemical hazard and exposure data.
  • To facilitate research by making vital information readily discoverable.

Main Methods:

  • A literature review was conducted using PubMed to identify relevant databases.
  • The inventory, named TEDI (Toxicological and Exposure Database Inventory), was established as a free, searchable online resource.
  • Meta-data was collected for databases focusing on chemical agents and human exposure, excluding quality assessments due to resource constraints.

Main Results:

  • A total of 715 databases were identified, cataloged, and described within TEDI.
  • Toxicological databases (n=362) contained a wide range of information, including toxicity data (57%) and physicochemical properties (38%).
  • Exposure databases (n=382) included exposure measurements (71%), web tools (21%), and risk assessment models (19%).

Conclusions:

  • TEDI offers significant value to the scientific community by supporting chemical health risk assessments.
  • The inventory is designed to be expandable, encouraging future additions to broaden its scope and data.
  • This resource aims to enhance the accessibility and utility of toxicological and exposure data for public health research.