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Non-bacterial thrombotic endocarditis: A state-of-the-art contemporary review

Mohammad Zmaili1, Jafar Alzubi2, Saberio Lo Presti Vega1

  • 1Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.

Progress in Cardiovascular Diseases
|October 24, 2022
PubMed

Insights

Non-bacterial thrombotic endocarditis (NBTE), a rare non-infective cardiac condition, is often misdiagnosed. Modern diagnostics are improving the evaluation and management of this thrombotic endocarditis.

Area of Science:

  • Cardiology
  • Pathology

Background:

  • Non-bacterial thrombotic endocarditis (NBTE), also known as marantic or Libman-Sacks endocarditis, is a non-infective cardiac condition.
  • It affects cardiac structures in patients with underlying predisposing conditions.
  • NBTE is rarely encountered and may be overlooked or misdiagnosed in clinical practice.

Purpose of the Study:

  • To provide a comprehensive review of NBTE.
  • To focus on contemporary diagnostic evaluation and management strategies for NBTE.

Main Methods:

  • Literature review of NBTE.
  • Analysis of diagnostic advancements.
  • Synthesis of current management approaches.

Main Results:

  • NBTE is a challenging diagnosis due to its rarity and potential for misdiagnosis.
  • Advanced diagnostic tools are enhancing the evaluation of NBTE.
  • Understanding of NBTE is expanding with improved diagnostic capabilities.

Conclusions:

  • Accurate diagnosis and timely management are crucial for patients with NBTE.
  • Continued research and awareness are needed to improve clinical outcomes.
  • Modern diagnostic and management strategies are essential for addressing NBTE.

Keywords:
Libman-Sacks endocarditisMarantic endocarditisNon-bacterial thrombotic endocarditisVerrucous endocarditis

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