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Related Concept Videos

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Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Assessment of the Cardiovascular System I: Subjective Data01:23

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A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Endocarditis I: Introduction01:25

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Updated: Aug 24, 2025

Murine Fecal Isolation and Microbiota Transplantation
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Human microbiome and cardiovascular diseases.

Md Jahangir Alam1, Vaishnavi Puppala1, Shravan K Uppulapu1

  • 1Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India.

Progress in Molecular Biology and Translational Science
|October 24, 2022
PubMed
Summary
This summary is machine-generated.

Gut microbes significantly impact cardiometabolic health through their metabolites. Dysbiosis, or an imbalanced gut microbiota, is linked to cardiovascular diseases (CVDs), highlighting the gut-metabolite-heart axis as a therapeutic target.

Keywords:
Cardiovascular diseasesMetabolitesMicrobiomeTherapeutics

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Area of Science:

  • Microbiology
  • Human Physiology
  • Metabolomics

Background:

  • The human gut harbors a complex microbiota, predominantly bacteria, crucial for host physiology.
  • Gut microbes metabolize dietary and endogenous compounds, producing metabolites vital for host-microbiota communication.
  • Gut dysbiosis is associated with numerous diseases, including metabolic disorders, immune dysfunction, and cardiovascular diseases (CVDs).

Purpose of the Study:

  • To explore the role of gut microbiota-dependent metabolites in cardiovascular disease (CVD) pathogenesis.
  • To discuss the influence of gut dysbiosis on CVD risk factors.
  • To examine the therapeutic potential of targeting the gut-metabolite-heart axis for CVD treatment.

Main Methods:

  • Literature review and synthesis of existing research on gut microbiota, metabolites, and cardiovascular health.
  • Analysis of the mechanisms linking gut dysbiosis to systemic inflammation and CVD.
  • Discussion of current research and future directions in the field.

Main Results:

  • Gut microbiota metabolites play a significant role in the pathological processes of CVDs.
  • Impaired intestinal barrier function can lead to the translocation of microbial products, contributing to systemic inflammation and CVD.
  • The gut-metabolite-heart axis represents a promising novel target for CVD therapeutic strategies.

Conclusions:

  • Gut microbiota composition and function are intrinsically linked to cardiometabolic health.
  • Targeting the gut-metabolite-heart axis offers a potential new avenue for preventing and treating cardiovascular diseases.
  • Further research is needed to fully elucidate the complex interactions and therapeutic possibilities.