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Updated: Aug 24, 2025

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[Type IVa2 urinary lithiasis and associated pathologies: About 3 cases]
Imen Gorsane1, Hayet Kaaroud2, Malek Karroubi3
1Service de néphrologie et de médecine A, hôpital Charles-Nicolle de Tunis, boulevard 9 Avril, Beb Souika, 1006 Tunis, Tunisie; Faculté de médecine de Tunis, Tunis, Tunisie; Laboratoire de recherche en immunologie de la transplantation rénale et immunopathologie (LR03SP01), hôpital Charles-Nicolle de Tunis, boulevard 9 Avril, Beb Souika, 1006 Tunis, Tunisie.
Introduction:
Urinary lithiasis is a very common condition. The morpho-constitutional analysis of urinary stones is important for etiological diagnosis. It guides the explorations and the specific management. Type IVa2 stones are rare, have particular morphology and correspond to very targeted pathologies. We propose to report our cases of patients diagnosed with type IVa2 urinary lithiasis.
Methods:
Our retrospective work focused on three cases of patients with the morphological type of renal lithiasis IVa2, collected between 2008 and 2020 in the Medicine A Department of Charles Nicolle Hospital in Tunis.
Results:
All three patients were female; average age 37.6 years. The clinical symptomatology was identical marked by renal colic with recurrent episodes. The presence of a type IVa2 stone, isolated or associated with other components, guided the etiological investigation to look for a secondary or primary cause of distal renal tubular acidosis. We retained the diagnosis of a primary hyperparathyroidism in one case and a primary Gougerot-Sjögren's syndrome in the second case, and probable in the last case.
Conclusion:
Determination of urolithiasis nature (morphological and chemical), although carried out late, was of major interest to us and allowed us to make the diagnosis of distal tubular acidosis.
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