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Impact of rotavirus vaccination on seizure hospitalizations in children: A systematic review

Jorge Arasa1, Mónica López-Lacort1, Javier Díez-Domingo2

  • 1Vaccines Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Avda. Cataluña, 21, 46020 Valencia, Spain.

Vaccine
|October 24, 2022
PubMed

Insights

Rotavirus (RV) vaccination may reduce hospitalizations for seizures in young children. However, inconsistent study designs and definitions limit definitive conclusions, necessitating further research.

Area of Science:

  • Pediatric infectious diseases
  • Vaccinology
  • Epidemiology

Background:

  • Conflicting evidence exists regarding the impact of rotavirus (RV) vaccination on seizure hospitalizations in children under five.
  • Understanding this association is crucial for public health recommendations and pediatric care.

Approach:

  • A systematic review of observational studies published since 2006 was performed.
  • Studies were identified through MEDLINE, with rigorous title/abstract, full-text review, and data extraction by two independent reviewers.

Key Points:

  • Thirteen studies met the inclusion criteria for the review.
  • Nine studies indicated a significant decrease in seizure hospitalizations following RV vaccine introduction.
  • Three studies found no significant impact, while one reported a rise in hospitalizations.

Conclusions:

  • Variability in study methodologies, case definitions, and potential biases hinder the quantification of RV vaccination's effect on seizure hospitalizations.
  • While RV vaccination shows potential for preventing seizure hospitalizations, more robust, well-designed studies are required to establish a definitive link.
Abstract

Keywords:
RotavirusRotavirus vaccineschildrenconvusionsseizures

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