Acute hepatic failure after open-heart surgery in children
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Updated: Sep 29, 2026
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Published on: July 18, 2014
Insights
This study reports two pediatric cases of acute hepatic failure and acute renal failure following open-heart surgery. Early diagnosis and careful vasopressor selection are crucial for managing this rare complication.
Area of Science:
- Pediatric Cardiology
- Hepatology
- Nephrology
Background:
- Acute hepatic failure (AHF) and acute renal failure (ARF) are known complications of adult open-heart surgery.
- Congenital heart disease correction via open-heart surgery can also lead to these complications in children.
Abstract:
Acute hepatic failure (AHF) combined with acute renal failure (ARF) is a well-known complication of open-heart surgery in adults. The occurrence of this complication in two children after open-heart surgery for correction of congenital heart disease is reported. Hypotension occurred during the operation and was treated by catecholamine vasopressors. AHF set in during the postoperative course; it was manifested by impaired consciousness, hypoglycemia, hyperbilirubinemia, hyperammonemia, elevated liver enzymes and prolongation of the prothrombin time with failure of hemostasis. ARF also developed in both children. One of the patients survived the acute episode of hepatic failure. The importance of early diagnosis, routine close monitoring, and appropriate selection of vasopressors is emphasized.
