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Updated: Aug 24, 2025

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Methylprednisolone-induced Acute Pancreatitis, a Case Presentation
Clara Wang-Liang1,2, Sarah Reid1, Jacob Barkley1
1Department of Medicine and Specialty Care Service, Louis A. Johnson VA Medical Center, Clarksburg, WV 26301, USA.
Drug-induced acute pancreatitis is rare, but methylprednisolone can cause it. This case highlights the importance of reviewing patient medications to diagnose pancreatitis causes.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Pharmacology
Background:
- Acute pancreatitis is a significant cause of hospitalization.
- Drug-induced acute pancreatitis accounts for 0.1-2% of cases.
- Over 100 medications are potential causes of drug-induced pancreatitis.
Observation:
- A 74-year-old male presented with acute pancreatitis symptoms.
- The patient had received high-dose methylprednisolone for three days.
- Other potential causes of pancreatitis were excluded.
Findings:
- The diagnosis of methylprednisolone-induced pancreatitis was confirmed.
- Treatment involved supportive care and methylprednisolone withdrawal.
- This case adds evidence to methylprednisolone as an etiological agent.
Implications:
- Diagnosing drug-induced pancreatitis can be challenging.
- Clinicians should consider medication history in unexplained pancreatitis cases.
- Methylprednisolone should be recognized as a potential cause of pancreatitis.
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