Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sovereign AI supercomputers: a global landscape review of unprecedented biomedical research infrastructure.

Frontiers in artificial intelligence·2026
Same author

Evaluating convolutional neural network models for automated abdominal aortic calcification scoring in chronic kidney disease patients across multiple centers.

Quantitative imaging in medicine and surgery·2026
Same author

Optimization of frailty indices in predicting the risk of surgical outcomes in patients undergoing spine surgery under nongeneral anesthesia.

The spine journal : official journal of the North American Spine Society·2026
Same author

Lung function trajectory: a partial mediator of the relationships between depressive symptoms and health-related quality of life in the aging population.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Comparison of AI-assisted quantitative collateral score and visual collateral score in stroke thrombectomy triage.

Neuroradiology·2026
Same author

Do Cannabis Users Require More Anesthesia During Third Molar Removal Under Intravenous General Anesthesia When Compared to Nonusers?

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·2026
Same journal

Improved Microplastic Identification from Simultaneously Collected Photothermal Infrared and Raman Spectra Using Multiview Conformal Prediction.

ACS measurement science au·2026
Same journal

Rapid Classification of Coffee Varieties Using Single-Bean Hot Gas Extraction Ion-Mobility Spectrometry with Machine Learning.

ACS measurement science au·2026
Same journal

Data-Driven Electrochemistry Reveals the Impact of Hydrophobicity on Aptamer Cross-Reactivity.

ACS measurement science au·2026
Same journal

Selective Preconcentration and Mass Spectrometry Profiling of Charged Extracellular Modified Ribonucleosides by Borate Complexation and Temperature-Assisted Ionic Liquid Microextraction.

ACS measurement science au·2026
Same journal

Transformation-Aware Molecular Networking for Interpretation of Untargeted LC-HRMS Data.

ACS measurement science au·2026
Same journal

Fully 3D-Printed Sampling-to-Detection Electrochemical Platform for Point-of-Care Measurement of Salivary Uric Acid.

ACS measurement science au·2026
See all related articles

Related Experiment Video

Updated: Aug 24, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

13.9K

Automatic Microtitrator for Small Volume Samples.

Zhizhen Wu1, Abid Rehman2, Zhehao Zhang1

  • 1Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois 60607, United States.

ACS Measurement Science Au
|October 25, 2022
PubMed
Summary
This summary is machine-generated.

A new automatic microtitration system precisely adjusts pH in small biomedical and environmental samples. This user-friendly technology enables rapid, accurate analysis for microvolume samples, overcoming limitations of manual titration.

More Related Videos

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
06:28

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration

Published on: February 2, 2024

852
Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

11.0K

Related Experiment Videos

Last Updated: Aug 24, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice
11:32

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

13.9K
Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration
06:28

Author Spotlight: Asymmetric Field Flow Fractionation for Bioreactor Integration

Published on: February 2, 2024

852
Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
11:20

Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology

Published on: March 21, 2018

11.0K

Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Environmental Science

Background:

  • Electroanalytical sensors require precise pH control for optimal performance in biomedical and environmental analyses.
  • Manual titration is impractical for small sample volumes, posing challenges in accuracy and time efficiency.
  • Existing automated titrators are not designed for microvolume sample handling.

Purpose of the Study:

  • To develop an automated microtitration system for precise pH adjustment in small-volume samples.
  • To validate the system's accuracy and efficiency with biological microsamples.
  • To assess the system's compatibility with trace metal analysis and potential for broader applications.

Main Methods:

  • Development of a novel, modular automatic microtitration system.
  • Validation using digested whole blood microsamples (as small as 100 μL).
  • Assessment of system-induced contamination during trace metal detection (manganese in blood).

Main Results:

  • The system successfully demonstrated accurate and rapid pH adjustment for microvolume samples (100 μL).
  • The modular design proved compatible with acid washing for trace metal analysis.
  • Electrochemical detection of manganese at parts per billion levels showed no system-induced contamination.

Conclusions:

  • The developed automatic microtitration system offers a simple, accurate, and user-friendly solution for pH adjustment in microvolume samples.
  • This technology addresses a critical gap in automated micro-pH analysis.
  • The system holds potential for various pH endpoint analyses and sample preparation steps in diverse fields.