Related Experiment Video
Updated: Aug 24, 2025

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
Preclinical activities of Cassia tora Linn against aging-related diseases
Sun-Young Hwang1, Chang-Su Na1, Byeong Cheol Moon2
1College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
Abstract:
Globally, an aging population is increasing, and aging is a natural physiological process and a major risk factor for all age-related diseases. It seriously threatens personal health and imposes a great economic burden. Therefore, there is a growing scientific interest in strategies for well-aging with prevention and treatment of age-related diseases. The seed, root, stem or leaves of Cassia tora Linn. are useful for anti-bacteria, anti-hyperlipidemia and anti-obesity due to its pharmacological activities such as anti-inflammation and anti-oxidant both in vitro and in vivo. Nevertheless, no clinical trials have been attempted so far, therefore here we would like to understand the current preclinical activities for aging-related disease models including cataract, metabolic dysfunction and neurodegeneration, then discuss their preparation for clinical trials and perspectives.
Insights
Cassia tora Linn. shows promise in preventing and treating aging-related diseases like cataracts, metabolic dysfunction, and neurodegeneration through its anti-inflammatory and antioxidant properties. Further preclinical research is needed before clinical trials can begin.
Area of Science:
- Gerontology and Pharmacology
- Natural Product Research
Background:
- Global aging population presents challenges for health and economy.
- Aging is a primary risk factor for numerous diseases.
- Scientific interest in well-aging strategies and age-related disease prevention is increasing.
Purpose of the Study:
- To review preclinical activities of Cassia tora Linn. for aging-related diseases.
- To assess the potential of Cassia tora Linn. in models of cataract, metabolic dysfunction, and neurodegeneration.
- To discuss the preparation and perspectives for future clinical trials.
Main Methods:
- Literature review of in vitro and in vivo preclinical studies.
- Analysis of pharmacological activities including anti-inflammation and anti-oxidant effects.
- Evaluation of Cassia tora Linn. in aging-related disease models.
Main Results:
- Cassia tora Linn. exhibits anti-bacterial, anti-hyperlipidemia, and anti-obesity properties.
- Pharmacological activities like anti-inflammation and anti-oxidation are demonstrated.
- Preclinical data suggests potential benefits for age-related conditions.
Conclusions:
- Cassia tora Linn. possesses significant potential for managing aging-related diseases.
- Further preclinical validation is essential.
- Clinical trial preparation and future research directions are discussed.
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues
Mitochondria
Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Alzheimer's Disease: Treatment
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...

