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Updated: Aug 24, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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[Fusion Genes in Cancer-Toward Treatment from a Pan-Cancer Perspective]

Shigenari Nukaga1, Takashi Kohno

  • 1Division of Genome Biology, National Cancer Center Research Institute.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 25, 2022
PubMed

Insights

Genetic testing identifies cancer fusion genes for targeted therapies. Understanding their function is crucial for advancing personalized cancer medicine.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Next-generation sequencing (NGS) is revolutionizing cancer drug therapy by enabling treatments based on individual genetic profiles.
  • Targeted drug development is actively pursuing various fusion genes identified through genetic testing.
  • The functional significance of many detected cancer fusion genes remains largely unknown, hindering personalized medicine advancements.

Approach:

  • This review synthesizes current knowledge on the molecular biology of cancer fusion genes.
  • It examines established and emerging methods for detecting these genetic alterations.
  • The review discusses current and future therapeutic strategies targeting fusion genes across various cancer types.

Key Points:

  • Fusion genes are critical targets in precision oncology.
  • Elucidating the biological function of fusion genes is essential for developing effective personalized treatments.
  • A pan-cancer perspective is necessary to understand the broad impact and therapeutic potential of fusion genes.

Conclusions:

  • Continued research into the function and detection of cancer fusion genes will accelerate the development of novel targeted therapies.
  • Understanding fusion gene biology is paramount for the future of personalized cancer medicine.
  • Targeting fusion genes offers a promising avenue for improving patient outcomes in oncology.

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