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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Sex Moderates the Association between Frailty and Mild Behavioral Impairment.

D X Guan1, K Rockwood, E E Smith

  • 1Zahinoor Ismail, 3280 Hospital Dr. NW Calgary AB, Canada T2N 4Z6, 403-210-6900, ismailz@ucalgary.ca, @11thCCD.

The Journal of Prevention of Alzheimer'S Disease
|October 25, 2022
PubMed
Summary

Frailty is linked to mild behavioral impairment (MBI) symptoms, particularly in males. Screening for frailty in MBI patients and MBI in frail individuals may aid early dementia risk detection.

Keywords:
Alzheimer’s diseaseFrailtydementiamild behavioral impairmentneuropsychiatric symptomsnon-cognitive dementia markers

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Area of Science:

  • Gerontology
  • Neuroscience
  • Psychiatry

Background:

  • Frailty is known to correlate with cognitive dementia markers.
  • The relationship between frailty and behavioral dementia markers remains unclear.

Purpose of the Study:

  • To examine the association between frailty and mild behavioral impairment (MBI).
  • To determine if sex moderates the frailty-MBI relationship.

Main Methods:

  • A cross-sectional study of 219 non-dementia participants.
  • Frailty Index (FI) and Mild Behavioral Impairment (MBI) symptoms were assessed.
  • Statistical analyses explored associations and sex-dependent effects.

Main Results:

  • Higher Frailty Index scores correlated with the presence and severity of MBI symptoms.
  • This association was sex-dependent, with males exhibiting higher MBI severity at higher frailty levels.
  • Specific MBI domains affected included decreased motivation, affective dysregulation, and psychosis.

Conclusions:

  • Frailty is associated with MBI presence and severity, notably in males.
  • Integrating frailty and MBI assessments may improve early dementia risk identification.