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Updated: Aug 24, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis
Floriane Calocer1, Huah Shin Ng1, Feng Zhu1
1Department of Medicine, Division of Neurology and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, UBC Hospital, Vancouver, BC, Canada.
Background:
The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood.
Objective:
To investigate the association between SES and mortality risk in PwMS.
Methods:
From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS 'onset') occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality.
Results:
Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36-1.91); SES-Q2 = 1.26 (95% CI = 1.05-1.50); SES-Q3 = 1.22 (95% CI = 1.02-1.46); SES-Q4 = 1.13 (95% CI = 0.94-1.35) versus SES-Q5 (least deprived).
Conclusion:
A lower SES was associated with higher mortality risk in PwMS.
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