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Bone construction surgery: A case report using recombinant human platelet-derived growth factor-BB.

George A Mandelaris^1,2,3, Bradley DeGroot¹

¹Private Practice, Periodontics and Dental Implant Surgery, Oakbrook Terrace and Glenview, Illinois, USA.

Clinical Advances in Periodontics

|October 25, 2022

Summary

This summary is machine-generated.

This case report details successful bone reconstruction for severe maxillary defects caused by peri-implantitis. The advanced technique utilized composite bone grafts and growth factors for functional implant restoration.

Keywords:

alveolar ridge augmentation biological products dental implants peri-implantitis

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Area of Science:

Dental Implantology
Regenerative Medicine
Periodontology

Background:

Bone condition is critical for dental implant success, requiring complex bone construction for mechanotransduction and soft tissue support.
Severe peri-implantitis can lead to significant bone defects, compromising implant viability and aesthetics.

Observation:

A patient with a severe anterior maxillary ridge defect from peri-implantitis underwent simultaneous implant removal and bone reconstruction.
A composite bone graft (allograft + xenograft) with recombinant human platelet-derived growth factor (rhPDGF-BB) was used.
Space maintenance was achieved with non-resorbable and absorbable membranes to ensure graft stability and wound healing.

Findings:

The 6-month healing process allowed for implant diagnostics and prosthetically directed placement using dynamic navigation.
Soft tissue augmentation and subsequent provisionalization completed the prosthetic phase.
The surgical outcome was successful both clinically and radiographically, demonstrating effective rehabilitation.

Implications:

This case highlights the successful management of severe bone loss due to peri-implantitis through advanced grafting techniques.
The importance of vascularized bone matrix formation and angiogenic therapeutics for long-term implant success is emphasized.
This approach offers a viable solution for complex anatomical reconstructions in implant dentistry.