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Risk factors for cardiovascular disease among individuals with hepatic steatosis

Julia Karády1,2, Maros Ferencik1,3, Thomas Mayrhofer1,4

  • 1Cardiovascular Imaging Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.

Hepatology Communications
|October 25, 2022
PubMed

Insights

Cardiovascular disease (CVD) risk factors in adults with hepatic steatosis (HS) are identified. Male sex, NT-proBNP, and ASCVD risk score are linked to coronary artery disease (CAD), while sedentary lifestyle and NT-proBNP predict major adverse cardiovascular events (MACE).

Area of Science:

  • Cardiology
  • Hepatology
  • Medical Imaging

Background:

  • Cardiovascular disease (CVD) is the primary cause of death in adults with hepatic steatosis (HS).
  • Risk factors for CVD in individuals with HS remain largely unknown.
  • Identifying these factors is crucial for improving patient outcomes and preventing cardiovascular events.

Purpose of the Study:

  • To identify factors associated with obstructive coronary artery disease (CAD) in adults with HS.
  • To determine predictors of incident major adverse cardiovascular events (MACE) in individuals with HS.
  • To aid in risk stratification for cardiovascular events in the HS population.

Main Methods:

  • A nested cohort study was conducted using data from the PROspective Multicenter Imaging Study for Evaluation of chest pain (PROMISE) trial.
  • Adults with HS detected via coronary computed tomography were analyzed.
  • Multivariate modeling and Cox regression were used to identify associations with obstructive CAD and MACE, adjusting for relevant covariates.

Main Results:

  • Obstructive CAD was present in 15.2% of individuals with HS.
  • Male sex, atherosclerotic CVD (ASCVD) risk score, and NT-proBNP were independently associated with obstructive CAD.
  • Sedentary lifestyle, NT-proBNP, and ASCVD risk score independently predicted MACE during follow-up.

Conclusions:

  • Male sex, NT-proBNP, and ASCVD risk score are associated with obstructive CAD in individuals with HS.
  • NT-proBNP, ASCVD risk score, and sedentary lifestyle are independent predictors of MACE in this population.
  • These identified factors may enhance risk stratification for cardiovascular events in adults with HS.

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