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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Mediators linking obesity to childhood asthma.

Yang-Ching Chen1,2,3,4, Yen-Tsung Huang5, Wen-Harn Pan6

  • 1Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|October 25, 2022
PubMed
Summary

Childhood obesity increases asthma risk, primarily through reduced physical fitness, impaired lung function, and early puberty. Interventions targeting these factors can mitigate this risk.

Keywords:
Mendelian randomization studyasthmamediation analysisobesitypulmonary function

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Area of Science:

  • Pediatric Health
  • Respiratory Medicine
  • Genetics

Background:

  • Obesity and asthma share a strong association in children, yet the underlying causal mechanisms require elucidation.
  • Key potential mediators include pulmonary function, airway inflammation, physical fitness, sleep-disordered breathing (SDB), and pubertal timing.

Purpose of the Study:

  • To investigate the causal pathways linking childhood obesity to asthma.
  • To quantify the mediating roles of pulmonary function, physical fitness, and early puberty in this association.

Main Methods:

  • A Mendelian randomization (MR) study incorporating mediation analysis on data from 5965 children (Taiwan Children Health Study).
  • Utilized MR two-stage least-squares and sensitivity analyses, complemented by prospective cohort analyses to establish temporal causality.

Main Results:

  • Obesity-associated asthma risk is significantly mediated by impaired pulmonary function (61.63%), low physical fitness (73.76%), and early puberty (27.66%).
  • Obesity negatively impacts lung function (FEV1/FVC) and physical fitness but is positively associated with early puberty.
  • Conversely, improved lung function and physical fitness reduce asthma risk, while SDB and early puberty increase it.

Conclusions:

  • Physical fitness and pulmonary function are critical mediators of obesity-induced asthma risk in children.
  • Interventions aimed at enhancing physical fitness and lung function hold promise for reducing childhood asthma prevalence in obese populations.