Related Experiment Video
Updated: Aug 24, 2025
A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
Significance of reduced renal function in patients with chronic myelomonocytic leukemia
Julia Heschl1, Klaus Geissler2,3
1Medical School, Sigmund Freud University, Vienna, Austria.
Insights
In patients with chronic myelomonocytic leukemia (CMML), nearly half showed increased creatinine levels. This finding indicates impaired renal function, which is linked to shorter survival and serves as a new prognostic marker.
Area of Science:
- Hematology
- Nephrology
- Oncology
Background:
- Chronic myelomonocytic leukemia (CMML) is a heterogeneous clonal hematopoietic stem cell disorder.
- Renal abnormalities are not well-characterized in CMML patients.
- Identifying prognostic markers is crucial for managing CMML.
Purpose of the Study:
- To determine the prevalence of increased creatinine levels in CMML patients.
- To investigate the prognostic impact of elevated creatinine on survival.
- To explore correlations between renal impairment and clinical, laboratory, and molecular features in CMML.
Main Methods:
- Retrospective analysis of 166 CMML patients.
- Assessment of creatinine levels (threshold > 1.1 mg/dL).
- Comparison of survival, clinical, laboratory, and mutation data between patients with and without renal impairment.
Main Results:
- Increased creatinine levels were observed in 71 of 166 (43%) CMML patients.
- Patients with elevated creatinine had significantly shorter median survival (20 vs. 52 months, p < 0.001).
- Renal impairment correlated with older age, male sex, higher leukocyte and monocyte counts, and elevated LDH; a trend towards higher CBL/ASXL1 mutations was noted.
Conclusions:
- Renal abnormalities, indicated by increased creatinine, are prevalent in CMML.
- Elevated creatinine serves as a novel, independent prognostic marker for reduced survival in CMML.
- These findings support considering renal function in the individualized management of CMML patients.
Abstract:
In a retrospective study, we analyzed the prevalence of increased creatinine levels in 166 patients with chronic myelomonocytic leukemia (CMML), their potential prognostic impact, and potential correlations with laboratory and molecular features. Increased creatinine values (> 1.1 mg/dl) were found in 71 of 166 (43%) patients. The median survival of patients with increased creatinine values was significantly shorter than in patients without impairment of renal function (20 vs. 52 months, p < 0.001). Patients with increased creatinine values were older, were more often male, had higher leukocyte counts, higher monocyte counts, and higher lactatdehydrogenase (LDH) values. There was a trend toward a higher prevalence of CBL and ASXL1 mutations in patients with renal impairment. Our findings show a high prevalence of renal abnormalities in patients with CMML. Increased creatinine values were identified as a new prognostic marker. These findings may be important for the individualized management of this heterogenous group of patients.
More Related Videos
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
12:05Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:11Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
01:28Chronic Kidney Disease III: Interprofessional Care
01:25Chronic Kidney Disease I: Introduction
01:27Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...