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Updated: Aug 24, 2025
The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
Published on: February 7, 2025
[Delta of neutrophil lymphocyte index and mortality in covid-19 disease]
Sandra Luz Rosales-López1, Juan Pablo Fernández-Hernández1, Martha Alicia Hernández-González2
1Instituto Mexicano del Seguro Social, Hospital de Especialidades No. 1 Bajío, Unidad de Cuidados Intensivos. León, Guanajuato, México.
Background:
Acute respiratory distress syndrome, due to SARS-CoV-2, is a worldwide health problem. The neutrophil-lymphocyte index allows risk stratification in patients with severe and poor prognostic data, since it reflects the inflammatory state.
Objective:
To determine whether the Neutrophil-Lymphocyte Index delta predicts mortality in patients with COVID-19.
Material And Methods:
We conducted a longitudinal, comparative study in patients with COVID-19, older than 18 years, admitted to the ICU. We evaluated HAS, DM, obesity, COPD, asthma, PaO2/FiO2, tomographic severity. On admission and on days 3 and 7 we measured Neutrophil-Lymphocyte Index, SOFA and APACHE score. For statistical analysis, we performed ROC and Kaplan-Meyer curves.
Results:
We included 180 patients with COVID-19, 63 died (35%). Delta INL1(Day1-day3)>4.11 was associated with mortality (AUC:0.633); sensitivity 55.56% and specificity 77.78%, CI95 0.55-0.70, for delta INL2 (Day1-day7)>8.95 (AUC:0.623); sensitivity 44.44% and specificity 84.62%, CI95 0.54-0.69. Difference in survival was observed for Delta1. SOFA scale >6, was associated with more days of mechanical ventilation and lower PaO2/FiO2 (p<0.001).
Conclusions:
INL delta between the day of ICU admission and the 3rd day of evolution is a predictor of mortality in critically ill patients.
