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Updated: Aug 24, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Efforts toward the Total Synthesis of Elisabethin A
Maximilian Kaiser1, David Schönbauer1, Katharina Schragl1
1Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060Wien, Austria.
Abstract:
We describe our efforts toward the total synthesis of the natural product elisabethin A. The first route was guided by the proposed biosynthesis, assembling the 6,6-ring system before forming the five-membered ring including the quaternary carbon. The second approach includes a high yielding cyclization under Mitsunobu conditions as a key step. It allowed the preparation of an unusual and highly functionalized bicyclic 6,5-spiro compound. Both routes share a common advanced precursor obtained from an "underdeveloped" Claisen rearrangement of an aryl dienyl ether.
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