Bootstrapped potential circadian harbingers if not determinants of cardiovascular risk

Among 12 endocrine variables in blood from clinically healthy adult women sampled systematically around the clock and the year, discriminant analysis methods have singled out certain hormones in certain seasons as classifiers for a high or low risk of developing diseases associated with a high circadian rhythm-adjusted mean (midline estimating statistic of rhythm, MESOR, M) of blood pressure, i.e., risk of M-hypertension (RMH). Before extending the labor intensive, costly data base, showing circadian changes with RMH, we reanalyzed available data by circadian bootstrapping, complementing earlier circannual bootstrapping. Differences in circadian M for aldosterone in all four seasons and for TSH in spring and summer (the only seasons checked), but not for the cortisol M checked in spring and summer, are validated, as are differences in circadian amplitude for TSH in spring and summer and aldosterone in spring. Identification of classifiers provides cost-effective, time-specified endocrine checks complementing the targeted automatic monitoring of blood pressure as part of a system of chronobioengineering for health maintenance.