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Ectodermal origins of the skin-brain axis: a novel model for the developing brain, inflammation, and

C Jameson1,2, K A Boulton1,2, N Silove2,3

  • 1Clinic for Autism and Neurodevelopmental Research, Brain and Mind Centre, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.

Molecular Psychiatry
|October 25, 2022
PubMed

Insights

Early skin barrier integrity may indicate neurodevelopmental differences in children. This review explores the skin-brain connection, linking atopic skin conditions to neurodivergence and potential early detection markers.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Immunology

Background:

  • Atypical neurodevelopment, including autism spectrum disorder, originates during early gestation.
  • Brain development is intertwined with epithelial barriers like the skin, gut, and airways.
  • Cutaneous atopic diseases are linked to impaired skin barrier function.

Purpose of the Study:

  • To review evidence connecting skin barrier integrity and neurodivergence.
  • To explore the shared developmental origins of skin and neural tissues.
  • To evaluate factors modifying the skin-brain connection in early life.

Main Methods:

  • Epidemiological data review
  • Neuroinflammatory evidence synthesis
  • Genetic and environmental risk factor analysis

Main Results:

  • Skin barrier integrity is linked to neurodevelopmental outcomes.
  • Early skin barrier function may serve as a marker for cortical integrity.
  • Skin barrier integrity can modify neurodevelopmental risk factors like immune activation.

Conclusions:

  • A novel skin-brain-neurodevelopment axis is proposed.
  • Initial skin barrier integrity may predict neurodevelopmental trajectories.
  • Understanding this connection can enhance early detection and intervention strategies for neurodevelopmental disorders.

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