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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
Flavonoids for the Treatment of Breast Cancer, Present Status and Future Prospective
Sonali Sahoo1,2, Priyanka Mohapatra1,2, Sanjeeb Kumar Sahoo1
1Institute of Life Sciences, Nalco Square, Bhubaneswar- 751023, Odisha, India.
Abstract:
Breast Cancer is one of the most notorious cancer affecting women globally. Current therapies available for breast cancer treatment have certain limited efficacy; develop drug resistance and severe adverse effects. Thus, identifying novel therapies for treatment will reduce the devastating effect on cancer survivors. The exhilarating and fastgrowing studies on flavonoids have evidenced that it has the potential to inflect various antitumor activity and modulate various signal transduction pathways in carcinogenesis. Flavonoids also have been found to regulate cellular metabolism and oxidative stress, cell cycle progression, angiogenesis and metastasis, ultimately preventing the progression of the diseases. As per the reports, a flavonoid-rich diet appears to be the most potent and promising approach to abate the risk of cancer. Thus, now a day, these are the prime target for drug discovery research. Based on existing findings, it can be concluded that beyond the currently employed chemotherapeutics, natural products (like flavonoids) exhibit pleiotropic, multi-target activities and are budding as possible complementary chemopreventive molecules against breast cancer with fewer side effects than conventional therapy. In this review, we comprehensively highlight an outline of the multiple pleiotropic pharmacological effects of various major classes of flavonoids on breast cancer with their specific mechanisms underlying its anticancer effect.
Insights
Flavonoids show significant potential as natural compounds to combat breast cancer, offering multi-target antitumor activities with fewer side effects than traditional chemotherapy.
Area of Science:
- Biochemistry and Molecular Biology
- Oncology
- Pharmacology
Background:
- Breast cancer poses a significant global health challenge, with current therapies exhibiting limited efficacy and notable side effects.
- The development of drug resistance necessitates the exploration of novel therapeutic strategies for breast cancer treatment.
- Flavonoids, a class of natural compounds, are increasingly recognized for their potential anticancer properties.
Approach:
- This review comprehensively outlines the pleiotropic pharmacological effects of major flavonoid classes on breast cancer.
- Mechanisms underlying the anticancer effects of flavonoids, including modulation of signal transduction pathways, are discussed.
- The role of flavonoids in regulating cellular metabolism, oxidative stress, cell cycle, angiogenesis, and metastasis is examined.
Key Points:
- Flavonoids exhibit diverse antitumor activities and can modulate key signaling pathways involved in carcinogenesis.
- Dietary intake of flavonoids may represent a promising approach to reduce cancer risk.
- Flavonoids demonstrate multi-target activities, suggesting their potential as complementary chemopreventive agents.
Conclusions:
- Flavonoids offer a promising avenue for novel breast cancer therapies due to their broad-spectrum anticancer effects.
- Natural products like flavonoids present an alternative or complementary approach to conventional chemotherapy, with a potentially improved side effect profile.
- Further research into flavonoids could lead to the development of effective and safer breast cancer treatments.
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