Complement use of Chinese herbal medicine after percutaneous coronary intervention: a prospective observational study

Si-Yu Yan1, Wei-Xian Yang1, Pei-Pei Lu1

  • 1Chinese Academy of Medical Sciences & Peking Union Medical College Fuwai Hospital, Xicheng District, Beijing, China.

Insights

Chinese herbal medicine use after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients was associated with a lower incidence of major adverse cardiovascular events (MACE). Further randomized studies are recommended to confirm these findings.

Area of Science:

  • Cardiovascular Medicine
  • Integrative Oncology
  • Pharmacology

Background:

  • Chinese herbal medicine is frequently used alongside conventional treatments for coronary artery disease (CAD) post-percutaneous coronary intervention (PCI).
  • This study investigated the impact of Chinese herbal medicine on major adverse cardiovascular events (MACE) in CAD patients after PCI.

Purpose of the Study:

  • To compare the incidence of MACE in CAD patients undergoing PCI, with and without the complementary use of Chinese herbal medicine.

Main Methods:

  • A prospective, observational study followed 5453 patients for two years post-PCI.
  • MACE (all-cause mortality, revascularization, myocardial infarction) was compared between patients using only Western medicine and those using Chinese herbal medicine adjunctively.
  • Unadjusted and risk-adjusted analyses (Kaplan-Meier, multivariable Cox regression) were performed.

Main Results:

  • The incidence of MACE was 15.3% in the Western medicine group and 11.54% in the integrative medicine group.
  • Cox regression analysis revealed a 27% lower cumulative incidence of MACE in patients using Chinese herbal medicine (HR=0.73, P<0.0001).

Conclusions:

  • Complementary use of Chinese herbal medicine in CAD patients after PCI is linked to reduced 2-year MACE incidence.
  • Further randomized controlled trials are necessary to establish definitive evidence of benefit.
Abstract

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