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Influence of mexiletine on caffeine elimination
Pharmacology & Therapeutics
|January 1, 1987
Abstract:
In an acute experiment in healthy volunteers and in patients under long-term treatment for cardiac arrhythmias, mexiletine inhibits caffeine elimination by about 50%. The clearance of mexiletine is not influenced by caffeine. Some side effects of mexiletine may possibly at least partially be attributable to a retention of caffeine.