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Non-coding antisense transcripts: fine regulation of gene expression in cancer
Francisco Santos1, Ana Maria Capela1, Francisca Mateus1
1Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.
Computational and Structural Biotechnology Journal
|October 26, 2022
Summary
Natural antisense transcripts (NATs) are RNA molecules with roles in health and disease. This study examines non-coding NATs in cancer, particularly their function as miRNA sponges.
Area of Science:
- Genomics
- Molecular Biology
- Cancer Research
Background:
- Natural antisense transcripts (NATs) are RNA molecules transcribed from the same genomic locus in the opposite direction.
- NATs are widely distributed in the human genome and involved in various physiological and pathological processes.
- NATs add complexity to genome organization and present potential therapeutic targets.
Purpose of the Study:
- To investigate the role of non-coding NATs in cancer.
- To focus on NATs functioning as microRNA (miRNA) sponges.
Main Methods:
- Literature review and analysis of existing data on NATs in cancer.
- Focus on mechanisms of non-coding NATs, especially miRNA sponging.
Main Results:
- Non-coding NATs play significant roles in cancer development and progression.
- NATs acting as miRNA sponges sequester miRNAs, affecting gene expression and cellular functions relevant to cancer.
Conclusions:
- Non-coding NATs, particularly miRNA sponges, represent a novel layer of gene regulation in cancer.
- Targeting these NATs could offer new therapeutic strategies for cancer treatment.
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