Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
Aging01:26

Aging

151
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
151
Mitochondria01:37

Mitochondria

14.2K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.2K
Longitudinal Research02:20

Longitudinal Research

12.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.1K
Genomics02:02

Genomics

36.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.9K
Telomeres and Telomerase02:41

Telomeres and Telomerase

5.3K
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The feeding habits of small-bodied fishes mediate the strength of top-down effects on plankton and water quality in shallow subtropical lakes.

Water research·2023
Same author

Adenovirus-IL-10 relieves chronic rejection after mouse heart transplantation by inhibiting miR-155 and activating SOCS5.

International journal of medical sciences·2023
Same author

Association between childhood sexual abuse and early sexual debut among Chinese adolescents: The role of sexual and reproductive health education.

Frontiers in reproductive health·2023
Same author

Effect of intraoperative dexmedetomidine on long-term survival in older patients after major noncardiac surgery: 3-year follow-up of a randomized trial.

Journal of clinical anesthesia·2023
Same author

Whole-genome resequencing reveals genetic differences and the genetic basis of parapodium number in Russian and Chinese Apostichopus japonicus.

BMC genomics·2023
Same author

VPAC2 receptor mediates VIP-potentiated insulin secretion via ion channels in rat pancreatic β cells.

Experimental cell research·2023

Related Experiment Video

Updated: Aug 24, 2025

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.2K

Strengthening Systematic Research on Aging: Reflections from an Omics Perspective.

Xiaoying Zheng1, Chao Guo2

  • 1School of Population Medicine and Public Health, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.

China CDC Weekly
|October 26, 2022
PubMed
Summary

Population aging presents complex health challenges. A new conceptual framework for human aging omics (HAO) aims to advance aging and health research by analyzing molecular and environmental factors across the lifespan.

Keywords:
Aging and healthHuman aging omicsOmicsSystematic research

More Related Videos

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.2K
Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

926

Related Experiment Videos

Last Updated: Aug 24, 2025

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.2K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.2K
Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

926

Area of Science:

  • Gerontology
  • Genomics
  • Biomolecular Sciences

Background:

  • Population aging is a significant global concern.
  • Health challenges in older adults are complex and require advanced research frameworks.
  • Existing research lacks a comprehensive approach to aging and health across the lifespan.

Purpose of the Study:

  • To introduce an advanced conceptual framework for human aging omics (HAO).
  • To define the scope, goals, and disciplines within HAO.
  • To propose a paradigm shift in aging and health research.

Main Methods:

  • Utilizing theories and methods from omics science.
  • Developing a systematic approach for identification, characterization, and quantification.
  • Integrating internal biomolecular data with external environmental factors.

Main Results:

  • The proposed HAO framework offers a comprehensive approach to studying aging.
  • It facilitates the systematic analysis of health conditions and their molecular underpinnings.
  • It enables the study of aging from birth to death throughout the lifespan.

Conclusions:

  • The human aging omics framework represents a paradigm shift in aging and health research.
  • HAO will enable a deeper understanding of the complex interplay between genetics, environment, and health during aging.
  • This framework is crucial for addressing the health challenges of an aging global population.