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Serum Uric Acid Is Associated with the Progression of Left Ventricular Diastolic Dysfunction in Apparently Healthy

Chen Die Yang1, Shuo Feng1, Jia Wei Chen2

  • 1Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Disease Markers
|October 26, 2022
PubMed

Insights

High serum uric acid (SUA) levels are linked to worsening left ventricular diastolic dysfunction (LVDD) in healthy individuals. This suggests SUA is an independent risk factor for developing LVDD, a key feature of heart failure with preserved ejection fraction.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Echocardiography

Background:

  • Left ventricular diastolic dysfunction (LVDD) defines heart failure with preserved ejection fraction (HFpEF).
  • Cardiometabolic risk factors are crucial in LVDD development.
  • Serum uric acid (SUA) is a potential cardiometabolic risk factor.

Purpose of the Study:

  • To investigate the association between serum uric acid (SUA) levels and the progression of LVDD.
  • To determine if SUA is an independent predictor of LVDD worsening in apparently healthy individuals.

Main Methods:

  • 1082 healthy subjects without cardiovascular disease or LVDD were enrolled.
  • Serum uric acid (SUA) levels were measured at baseline.
  • Repeat echocardiography and tissue Doppler imaging (TDI) were performed over a 1-year follow-up.

Main Results:

  • Higher SUA quartiles correlated with increased E/e' ratios and early diastolic velocity (e') over 1 year.
  • High SUA remained an independent predictor of LVDD worsening after multivariate adjustment (OR: 1.351).
  • The association was stronger in individuals without other cardiometabolic risk factors.

Conclusions:

  • Elevated serum uric acid (SUA) is an independent risk factor for left ventricular diastolic dysfunction (LVDD) progression.
  • SUA is a significant cardiometabolic attribute associated with LVDD worsening.
  • These findings highlight SUA's role in subclinical cardiac dysfunction.
Abstract

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