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A rare case of multiple eccrine hidrocystoma with severe hyperhidrosis successfully treated with botulinum toxin-A

Hongyu Zhou1, Yeqin Dai2, Ping Wang2

  • 1Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, China.

The Australasian Journal of Dermatology
|October 26, 2022
PubMed
Abstract

No abstract available in PubMed .

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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