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Updated: Aug 24, 2025
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
The relationship between platelet distribution width and new-onset cardiovascular disease events in patients with
Ning Su1,2, Xingming Tang3, Xiaojiang Zhan4
1Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Insights
High platelet distribution width (PDW) is linked to increased cardiovascular disease (CVD) risk in patients undergoing peritoneal dialysis (PD). This finding suggests PDW may serve as a valuable prognostic marker for CVD in this population.
Area of Science:
- Nephrology
- Cardiology
- Hematology
Background:
- Chronic kidney disease (CKD) mortality is rising globally.
- Peritoneal dialysis (PD) is a key treatment for end-stage renal disease.
- Cardiovascular disease (CVD) is the primary complication and cause of mortality in PD patients.
Purpose of the Study:
- To investigate the association between platelet distribution width (PDW) and new-onset CVD in PD patients.
- To clarify the prognostic value of PDW for adverse cardiovascular events in this cohort.
Main Methods:
- Retrospective cohort study including 1557 PD patients from 2005-2019.
- Patients categorized by PDW levels (≤13.2 fL vs. >13.2 fL).
- Cox proportional hazards models and ROC curves used to analyze CVD event risk and predictive accuracy.
Main Results:
- 114 new-onset CVD events occurred during follow-up.
- High PDW was significantly associated with a higher risk of CVD events (HR = 1.862, p=0.005).
- Kaplan-Meier curves confirmed increased CVD risk in the high PDW group (p=0.006).
Conclusions:
- Elevated PDW is a significant predictor of new-onset CVD in patients undergoing peritoneal dialysis.
- PDW may serve as a valuable biomarker for cardiovascular risk stratification in PD patients.
Objectives:
The global mortality rate from chronic kidney disease (CKD) has increased over the past two decades. Typically, peritoneal dialysis (PD) remains a useful alternative treatment for end-stage renal disease. Cardiovascular disease (CVD) is the main complication in PD patients. In terms of prognosis, it is reported that platelet distribution width (PDW) can predict adverse CVD events. However, the relationship between PDW and new-onset CVD in PD patients is not clear. This study aimed to explore the relationship between PDW and new-onset CVD in PD patients.
Methods:
This was a retrospective cohort study, from 4 July 2005 to 31 December 2019, and a total of 1557 patients were recruited. PDW was respectively categorized into two groups: PDW ≤13.2 fL and PDW >13.2 fL. The primary outcome was a new-onset CVD event. Cox proportional hazards models were performed to assess the hazard ratio (HR). Receiver-operating characteristic (ROC) curves were applied to evaluate the predictive accuracy of the PDW on CVD events.
Results:
During follow-up, 114 new-onset CVD events were recorded. Cox proportional hazards models showed a higher risk of CVD events in patients with high PDW (HR = 1.862 95%CI 1.205-2.877, p = 0.005). Kaplan-Meier cumulative incidence curves showed the risk of the first occurrence of CVD events was greater in the high PDW group (p = 0.006).
Conclusions:
High PDW is associated with new-onset cardiovascular disease events in PD patients.
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