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Updated: Aug 24, 2025
Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
[CME: Neuroborreliosis]
Laura Iven-Assmann1, Katarzyna Szajek1, Rolf Sturzenegger2
1Innere Medizin, Kantonsspital Graubünden, Schweiz.
Neuroborreliosis, a neurological complication of Lyme disease, affects 3-15% of cases. Early antibiotic treatment is crucial for preventing disseminated infection and neurological symptoms like meningitis or polyradiculitis.
Area of Science:
- Infectious Diseases
- Neurology
- Microbiology
Context:
- Lyme disease, caused by *Borrelia burgdorferi* bacteria, is prevalent in Europe.
- Tick bites are the primary transmission vector to humans.
- Untreated Lyme disease can lead to disseminated infections.
Purpose:
- To outline the presentation, diagnosis, and treatment of neuroborreliosis.
- To discuss the incidence and potential neurological manifestations of Lyme disease.
- To highlight prevention strategies and ongoing vaccine development.
Summary:
- Neuroborreliosis, a neurological manifestation of Lyme disease, occurs in 3-15% of infected individuals.
- Clinical presentations include polyradiculitis, meningitis, and encephalomyelitis.
- Effective antimicrobial therapies include doxycycline, ceftriaxone, and penicillin G.
Impact:
- Informing clinicians about the neurological sequelae of Lyme disease.
- Guiding appropriate antimicrobial selection for neuroborreliosis treatment.
- Emphasizing the importance of exposure prophylaxis and future vaccination efforts.
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