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Updated: Aug 24, 2025

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
Published on: November 12, 2019
Real-time, closed-loop, or open-loop stimulation? Navigating a terminological jungle
James W Antony1, Hong-Viet V Ngo2,3, Til Ole Bergmann4,5
1Department of Psychology and Child Development, California Polytechnic State University, San Luis Obispo, California, USA.
Abstract:
Recent advancements in real-time brain stimulation in the sleep field have led to many exciting findings. However, they have also opened up terminological ambiguities about what constitutes "open-loop", "closed-loop", and "real-time" designs. Here, we address core theoretical aspects of these terms in the hopes of strengthening future research on this topic.
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