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Updated: Aug 24, 2025

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
Published on: March 8, 2024
Management of hyperinflammation in COVID-19 patients
1Borja Suberviola, Servicio de Medicina Intensiva. Hospital Universitario Marqués de Valdecilla-IDIVAL. Santander, Spain. borjasuberviola1977@gmail.com.
Abstract:
In response to SARS-CoV-2 infection, the immune system physiologically upregulates to try to clear the virus from the body; failure to compensate for this inflammatory response with an anti-inflammatory response leads to dysregulation of the immune system that ultimately leads to a situation of uncontrolled hyperinflammation called cytokine storm. This cytokine storm can cause ARDS or multi-organ failure leading to patient death. This review exposes the different mechanisms of the inflammatory response in COVID-19 infection and the therapeutic options to treat this process.
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