COVID-19 in donation and transplant

Area of Science:

• * Infectious Diseases
• * Transplant Surgery
• * Public Health

Background:

• * The COVID-19 pandemic significantly disrupted organ donation and transplantation globally.
• * Rapid generation of scientific evidence has been crucial for resuming and expanding transplant activities.

Purpose of the Study:

• * To analyze the epidemiology and burden of COVID-19 in donation and transplantation.
• * To explore the pathogenesis of SARS-CoV-2 and its link to graft transmission.
• * To assess the impact of vaccination and available therapeutics on transplant outcomes.

Main Methods:

• * Literature review and analysis of epidemiological data.
• * Examination of scientific evidence on SARS-CoV-2 infection in donors and recipients.
• * Evaluation of vaccination strategies and therapeutic interventions.

Main Results:

• * COVID-19 presents complex challenges in donation and transplantation, including potential graft transmission.
• * Vaccination offers protection but requires careful consideration in transplant populations.
• * Therapeutic advancements are improving outcomes for infected transplant recipients.

Conclusions:

• * A comprehensive understanding of COVID-19's impact is vital for safe and effective donation and transplantation.
• * Continued research and adaptation of protocols are necessary to manage the pandemic's long-term effects.
• * Evidence-based strategies support the resumption and growth of organ transplantation.