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Norovirus infection as a model of chronic or recurrent infection in common variable immunodeficiency
P Moral Moral1, D Cabañero-Navalon, V Garcia-Bustos
1Pedro Moral Moral, Primary Immunodeficiencies Unit. Internal Medicine Section. University and Polytechnic Hospital La Fe. Valencia, Spain. pedromoralmoral@hotmail.com.
Abstract:
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency (PID) in general population. PID are genetic diseases that share a dysfunction in the immune system entailing a greater risk of both chronic and recurrent infections. These patients can also develop chronic gastrointestinal infections caused by norovirus with persistent viral dissemination, which can be detected months after primoinfection. Additionally, a proportion of CVID patients show a typical severe enteropathy presenting with recurrent diarrhoea, intestinal malabsorption, inflammatory lesions, and villous atrophy. Some studies have related this enteropathy with chronic intestinal infection caused by norovirus.
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