Dioxetane Derivative Containing Carboxy Group as a Chemiluminophore-Introducing Reagent
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Updated: Aug 24, 2025

A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
Published on: March 9, 2017
Yukie Nohara1, Shun Masuda1, Kazuko Kaneda-Nakashima2,3
1Peptide Institute, Inc., Osaka, Japan.
Abstract:
Some types of dioxetanes are called chemiluminophores because they produce luminescence light without the use of enzymes. Here, we designed and synthesized a novel carboxy group-containing chemiluminophore derivative, which enabled the simple introduction of such a chemiluminophore to the molecule of interest. Furthermore, we demonstrate that the in vivo imaging system (IVIS imaging system) can recognize tagged chemicals, indicating that such a chemiluminophore could be employed as a tracer molecule for biological studies.
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