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Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants
Pathum Chandika1,2, Pipuni Tennakoon1,3, Tae-Hee Kim1,2
1Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Korea.
Marine Drugs
|October 26, 2022
Summary
Marine natural products offer promising alternatives to heparin anticoagulants. This review explores marine flora and fauna for novel anticoagulants to address limitations of current therapies and prevent cardiovascular diseases.
Area of Science:
- Biochemistry
- Pharmacology
- Marine Biology
Background:
- Coagulation is a vital defense mechanism converting fibrinogen to fibrin clots.
- Imbalances in coagulation can lead to abnormal clot formation, causing cardiovascular diseases.
- Heparin anticoagulants have limitations including unpredictable effects and bleeding risks.
Purpose of the Study:
- To review the coagulation cascade.
- To explore potential macromolecular anticoagulants from marine sources.
- To highlight marine natural products as alternatives to heparin.
Main Methods:
- Literature review of coagulation pathways.
- Survey of marine organisms for anticoagulant properties.
- Analysis of chemical structures and biological activities of marine anticoagulants.
Main Results:
- Coagulation cascade involves sequential activation of zymogens.
- Marine flora and fauna possess unique compounds with anticoagulant activity.
- These marine compounds show potential for safe and effective anticoagulation.
Conclusions:
- Marine natural products represent a promising source for novel anticoagulants.
- Further research into marine anticoagulants could lead to improved therapies for thrombotic disorders.
- Investigating marine sources offers a viable strategy to overcome heparin's clinical limitations.
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