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[Myocardial remodeling in patients with chronic heart failure and implanted cardiac contractility modulators]

A A Safiullina1, T M Uskach1,2, S V Dobrovolskaya1

  • 1National Medical Research Center of Cardiology.

Terapevticheskii Arkhiv
|October 26, 2022
PubMed

Insights

Cardiac contractility modulation (CCM) therapy positively impacts left ventricular remodeling and myocardial function in chronic heart failure (HF) patients with atrial fibrillation (AF). Echocardiography effectively monitors these improvements.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Context:

  • Chronic heart failure (HF) with atrial fibrillation (AF) presents complex challenges in cardiac function and remodeling.
  • Assessing therapeutic interventions for HF requires robust imaging and functional analysis.

Purpose:

  • To investigate the impact of cardiac contractility modulation (CCM) on reverse remodeling and myocardial function in patients with chronic HF.
  • To evaluate the effectiveness of CCM therapy using echocardiography (EchoCG).

Summary:

  • A 12-month study analyzed 40 patients with chronic HF and AF undergoing CCM therapy.
  • Standard EchoCG parameters and left ventricular (LV) myocardial work were assessed.
  • Results showed a statistically significant positive effect of CCM on LV remodeling and myocardial work.

Impact:

  • Transthoracic echocardiography is crucial for evaluating HF treatment efficacy, including non-pharmacological methods like CCM.
  • Assessing LV myocardial function in HF patients with CCM devices offers a promising research avenue.
Abstract

Keywords:
atrial fibrillationcardiac contractility modulationechocardiographyheart failuremyocardial work

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