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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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[COVID-19 and the small intestine].
S D Bakharev1, E V Baulo1, S V Bykova1
1Loginov Moscow Clinical Scientific Center.
Terapevticheskii Arkhiv
|October 26, 2022
Summary
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE-2) to infect cells, frequently impacting the intestines. This review details SARS-CoV-2
Area of Science:
- Virology
- Gastroenterology
- Cell Biology
Context:
- Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection, commonly known as COVID-19, primarily affects the respiratory system.
- The angiotensin-converting enzyme 2 (ACE-2) receptor is a critical entry point for SARS-CoV-2 into host cells.
- ACE-2 receptors are highly expressed in lung tissue but also significantly present in the small intestine's enterocytes.
Purpose:
- To elucidate the mechanisms by which SARS-CoV-2 interacts with intestinal enterocytes.
- To explore the fecal-oral transmission route of SARS-CoV-2.
- To review the diagnostic and therapeutic strategies for managing intestinal symptoms associated with COVID-19.
Summary:
- SARS-CoV-2 infection involves the binding of the virus to ACE-2 receptors on host cells.
- The small intestine, rich in ACE-2, is a significant site for viral entry and replication, leading to gastrointestinal manifestations.
- Understanding these interactions is crucial for managing the multifaceted clinical presentation of COVID-19, including its intestinal complications.
Impact:
- Provides insights into the gastrointestinal pathology of COVID-19.
- Highlights the importance of considering the fecal-oral route in SARS-CoV-2 transmission and control.
- Informs clinical practice regarding the diagnosis and treatment of patients with both respiratory and intestinal symptoms of COVID-19.
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