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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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[COVID-19 and features of cardiovascular involvement]

E V Tsyganova1, N V Glukhoedova1, A S Zhilenkova1

  • 1Moscow City Center for the Prevention and Control of AIDS.

Terapevticheskii Arkhiv
|October 26, 2022
PubMed

Insights

This review details the pathogenesis of COVID-19, focusing on inflammation, coagulopathy, and organ damage. It highlights the roles of ACE2 and TMPRSS2 in COVID-19 pathology and cardiovascular complications.

Area of Science:

  • Virology
  • Pathology
  • Cardiology

Context:

  • COVID-19 pathogenesis involves complex interactions.
  • Organ-specific lesions are a hallmark of severe disease.
  • Understanding molecular mechanisms is crucial for treatment.

Purpose:

  • To provide a comprehensive overview of COVID-19 pathogenesis.
  • To detail organ-specific lesions and their underlying mechanisms.
  • To elucidate the role of key receptors and biochemical markers.

Summary:

  • Discusses inflammation, coagulopathy, endothelial damage, and microthrombosis in COVID-19.
  • Explains the function of angiotensin-converting enzyme type 2 (ACE2) and transmembrane serine protease type 2 (TMPRSS2) receptors.
  • Presents findings on cardiovascular damage, including myocardial changes and echocardiographic results.

Impact:

  • Informs researchers on COVID-19 disease mechanisms.
  • Aids clinicians in diagnosing and managing organ-specific complications.
  • Contributes to the development of targeted therapies for COVID-19.

Keywords:
COVID-19coagulationinflammationmyocardial changesthrombosistransthoracic echocardiography

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