[Liver cirrosis and complication risk management]

Area of Science:

• Gastroenterology and Hepatology
• Microbiology
• Pathophysiology

Context:

• Liver cirrhosis (LC) is a leading cause of digestive system mortality and complications.
• Effective prevention strategies for LC progression and complications are urgently needed.
• The gut-liver axis is increasingly recognized for its role in LC pathogenesis.

Purpose:

• To provide updated information on the role of intestinal microbiota, endotoxemia, and intestinal permeability in liver cirrhosis.
• To present findings from meta-analyses on dysbiosis and LC prognosis.
• To highlight the significance of the gut-liver axis in managing LC complications.

Summary:

• Dysbiosis, endotoxemia, and increased intestinal permeability are critical factors in liver cirrhosis pathophysiology.
• Meta-analyses confirm the negative impact of gut dysbiosis on LC prognosis.
• Interventions targeting gut microbiota show potential for correcting dysbiotic disorders.
• The gut-liver axis is a central pathway in the development of major LC complications.

Impact:

• Understanding the gut-liver axis provides novel insights into managing liver cirrhosis.
• Modulating intestinal microbiota may offer therapeutic avenues for preventing LC complications.
• This knowledge advances the development of targeted interventions for liver disease patients.