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Hypertension I: Introduction01:28

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
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Articles linked to this work by shared authors, journal, and citation graph.

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[Diagnosis and management of patients with pheochromocytoma/paraganglioma: Consensus of experts of the Russian Medical Society for Arterial Hypertension and the Multidisciplinary Group for the Diagnosis and Treatment of Neuroendocrine Tumors].

Terapevticheskii arkhiv·2024
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[Primary hyperaldosteronism: indications for screening].

N M Chikhladze1

  • 1National Medical Research Center of Cardiology.

Terapevticheskii Arkhiv
|October 26, 2022
PubMed
Summary

Screening for primary hyperaldosteronism (PHA) is crucial for identifying a common cause of high blood pressure (hypertension). Early PHA detection and treatment can reduce cardiovascular risks associated with excess aldosterone.

Keywords:
arteral hypertensionprimary hyperaldosteronismscreening

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Area of Science:

  • Endocrinology
  • Cardiology
  • Hypertension Research

Context:

  • Primary hyperaldosteronism (PHA) is an underdiagnosed cause of arterial hypertension (AH).
  • Current screening practices for PHA in hypertensive patients are often inadequate.
  • Methodological challenges hinder accurate PHA diagnosis and prevalence assessment.

Purpose:

  • To review the current status of screening for primary hyperaldosteronism (PHA) in patients with arterial hypertension (AH).
  • To analyze screening criteria and identify methodological errors impacting PHA diagnosis.
  • To emphasize the need for improved PHA screening and diagnosis to manage uncontrolled AH.

Summary:

  • This review examines the challenges and criteria for screening patients for primary hyperaldosteronism (PHA), a significant contributor to arterial hypertension (AH).
  • It highlights low screening rates and discusses diagnostic pitfalls, advocating for better physician education on PHA detection.
  • The analysis focuses on identifying high-risk AH populations for PHA development and assessing prevalence.

Impact:

  • Improved screening and timely diagnosis of PHA can lead to targeted treatment.
  • Effective management of PHA can reduce cardiovascular complications linked to aldosterone excess.
  • Increased awareness and familiarization with PHA diagnostic methods are essential for managing resistant hypertension.