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[Epithelial protective therapy in comorbid diseases. Practical Guidelines for Physicians].
V I Simanenkov1, I V Maev2, O N Tkacheva3
1Mechnikov North-Western State Medical University.
Terapevticheskii Arkhiv
|October 26, 2022
Summary
This guideline provides evidence-based recommendations for physicians on managing Increased Epithelial Permeability Syndrome. It details epithelial protective drugs like proton pump inhibitors, bismuth drugs, probiotics, and rebamipide.
Area of Science:
- Gastroenterology
- Internal Medicine
- Pharmacology
Context:
- The 2021 National Consensus on Increased Epithelial Permeability Syndrome (IEPS) established a foundation for understanding the condition.
- This document builds upon the 2021 Consensus, offering practical guidance for clinicians.
- Expert consensus was achieved using the Delphi method to develop 28 physician statements.
Purpose:
- To provide evidence-based practical guidelines for physicians managing IEPS.
- To update and expand upon the initial national consensus on IEPS.
- To detail the clinical and pharmacological properties of epithelial protective agents.
Summary:
- The guidelines review key drug classes for epithelial protection, including proton pump inhibitors, bismuth compounds, and probiotics, based on evidence-based medicine.
- Focuses on rebamipide as a comprehensive epithelial protector with pre-epithelial, epithelial, and sub-epithelial actions.
- Covers the entire gastrointestinal tract, offering a unified approach to IEPS management.
Impact:
- Aims to improve clinical practice and patient outcomes in managing IEPS.
- Facilitates consistent and effective application of evidence-based treatments for IEPS.
- Enhances understanding and utilization of epithelial protective therapies in gastroenterology.
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