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Related Concept Videos

Transmission-based Precautions II: Airborne and Protective Environment01:25

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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
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Standard Precaution01:26

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Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
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Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

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Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Related Experiment Video

Updated: Aug 24, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
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[Epithelial protective therapy in comorbid diseases. Practical Guidelines for Physicians].

V I Simanenkov1, I V Maev2, O N Tkacheva3

  • 1Mechnikov North-Western State Medical University.

Terapevticheskii Arkhiv
|October 26, 2022
PubMed
Summary

This guideline provides evidence-based recommendations for physicians on managing Increased Epithelial Permeability Syndrome. It details epithelial protective drugs like proton pump inhibitors, bismuth drugs, probiotics, and rebamipide.

Keywords:
comorbid diseases of the digestive systemepithelial protective therapyincreased epithelial permeability syndromerebamipide

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Last Updated: Aug 24, 2025

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Pharmacology

Context:

  • The 2021 National Consensus on Increased Epithelial Permeability Syndrome (IEPS) established a foundation for understanding the condition.
  • This document builds upon the 2021 Consensus, offering practical guidance for clinicians.
  • Expert consensus was achieved using the Delphi method to develop 28 physician statements.

Purpose:

  • To provide evidence-based practical guidelines for physicians managing IEPS.
  • To update and expand upon the initial national consensus on IEPS.
  • To detail the clinical and pharmacological properties of epithelial protective agents.

Summary:

  • The guidelines review key drug classes for epithelial protection, including proton pump inhibitors, bismuth compounds, and probiotics, based on evidence-based medicine.
  • Focuses on rebamipide as a comprehensive epithelial protector with pre-epithelial, epithelial, and sub-epithelial actions.
  • Covers the entire gastrointestinal tract, offering a unified approach to IEPS management.

Impact:

  • Aims to improve clinical practice and patient outcomes in managing IEPS.
  • Facilitates consistent and effective application of evidence-based treatments for IEPS.
  • Enhances understanding and utilization of epithelial protective therapies in gastroenterology.