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Flow cytometry as a fast, cost-effective tool to assess IGHV mutational status in CLL

Guillaume Couillez1, Pierre Morel2, Valentin Clichet1

  • 1Service d'Hématologie Biologique, Centre de Biologie Humaine, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.

Blood Advances
|October 26, 2022
PubMed
Abstract

No abstract available in PubMed .

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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