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Muscles of the Pelvic Floor and Perineum01:26

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The muscles of the pelvic floor and perineum are crucial for supporting the pelvic organs, controlling continence, and aiding in sexual function, childbirth, and core stability. They are typically divided into the superficial perineal layer and the deep pelvic floor layer.
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Current practice in animal models for pelvic floor dysfunction.

Fei Fang1,2, Zhiwei Zhao2, Jingyue Xiao2

  • 1Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, West China Campus, Chengdu, 610041, Sichuan Province, China.

International Urogynecology Journal
|October 26, 2022
PubMed
Summary
This summary is machine-generated.

Researchers reviewed animal models for female pelvic floor dysfunction (PFD). Rats are most applicable, with vaginal dilation a common method for studying PFD pathogenesis and treatment.

Keywords:
Animal modelPelvic floor dysfunctionPelvic organ prolapseStress urinary incontinence

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Area of Science:

  • Reproductive Biology
  • Biomedical Engineering
  • Veterinary Medicine

Background:

  • Female pelvic floor dysfunction (PFD) affects a significant portion of the female population.
  • Understanding the pathophysiology of PFD is crucial for developing effective treatments.
  • Animal models are essential tools for preclinical research into PFD.

Purpose of the Study:

  • To systematically review current animal models used for studying female pelvic floor dysfunction (PFD).
  • To evaluate the suitability of different animal species and modeling techniques for PFD research.

Main Methods:

  • A comprehensive literature search was conducted using keywords 'PFD' and 'animal models' in PubMed, Ovid-Medline, and Ovid-Embase from 2000 to 2022.
  • Publications detailing the construction and application of animal models for PFD were included.
  • Results were synthesized and presented through narrative text.

Main Results:

  • Rodents, large quadrupeds, and nonhuman primates (NHPs) are the primary animal models used for PFD studies.
  • NHPs offer the closest anatomical and biomechanical similarity to humans, particularly for pelvic organ prolapse.
  • Rodents are suitable for molecular and histopathological studies, while large quadrupeds aid biomechanical research and surgical instrument development.
  • Common modeling methods include muscle destruction, hormone level regulation, denervation, and gene knockout.
  • Vaginal dilation is a widely used method for investigating PFD pathogenesis and treatment efficacy.

Conclusions:

  • Rats are currently the most versatile animal model for various PFD modeling techniques.
  • Vaginal dilation stands out as a prevalent method for studying PFD's pathology and therapeutic interventions.