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Vitamin D in the older population: a consensus statement.

Andrea Giustina1, Roger Bouillon2, Bess Dawson-Hughes3

  • 1Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS Hospital, Milan, Italy.

Endocrine
|October 26, 2022
PubMed
Summary
This summary is machine-generated.

Vitamin D supplementation, combined with calcium, helps reduce fractures in older adults. Daily low-dose vitamin D is recommended over large doses to prevent falls and manage deficiency, aiming for serum levels above 50 nmol/l.

Keywords:
AgingOlder peopleVitamin DVitamin D deficiencyVitamin D supplementation

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Endocrinology

Background:

  • The 5th International Conference "Controversies in Vitamin D" convened in September 2021, focusing on timely and debated topics in Vitamin D research.
  • This paper disseminates key findings from the conference, emphasizing Vitamin D's role in aging.
  • Annual conferences since 2017 aim to share up-to-date Vitamin D information with healthcare professionals.

Purpose of the Study:

  • To identify and discuss controversial issues surrounding Vitamin D and aging.
  • To review current literature on Vitamin D's impact on the aging population.
  • To foster consensus on optimal Vitamin D strategies for older adults.

Main Methods:

  • Experts reviewed literature on assigned topics concerning Vitamin D and aging.
  • Presentations stimulated discussion on Vitamin D production, skeletal effects, falls, extra-skeletal effects, and deficiency prevention.
  • A specific focus was placed on Vitamin D's influence on COVID-19 vaccine efficacy.

Main Results:

  • Aging impacts Vitamin D production and levels, increasing deficiency risk in older adults.
  • Vitamin D deficiency is linked to reduced bone density, fractures, increased falls, and potential extra-skeletal issues like diabetes and cardiovascular disease.
  • Strategies to combat deficiency include sun exposure, food fortification, and supplementation, with supplementation being the most practical for the aging population.

Conclusions:

  • Consensus reached: Vitamin D supplementation with calcium reduces fractures in the elderly.
  • Recommended serum 25(OH)D levels should exceed 50 nmol/l.
  • Daily low-dose Vitamin D is preferred for fall prevention; its role in muscle strength needs further research. Supplementation aids in preventing T2D progression in deficient individuals.