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Updated: Aug 24, 2025
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence
Maria da Penha Gomes Gouvea1, Isac Ribeiro Moulaz2, Thayná Martins Gouveia2
1Universidade Federal do Espírito Santo, Hospital Universitário Cassiano Antonio Moraes, Vitória, ES, Brasil.
Background:
This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence.
Methods:
The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N.
Results:
Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms.
Conclusions:
Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence.
