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A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection
Marina Lobato Martins1, Maria Clara Fernandes da Silva-Malta1, Argus Leão Araújo2
1Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
Background:
The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19).
Methods:
We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC).
Results:
The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis.
Conclusions:
SC, as well as AS was characterized by an inflammatory profile.
